Founding members of the International Adductomics Consortium

Marcus S. Cooke

Marcus S. Cooke is a Professor and the Chair of the Department of Molecular Biosciences at the University of South Florida, and is also a member of the Cancer Biology and Evolution Program, Moffitt Cancer Center. His PhD, at the joint University of Leicester/Medical Research Council Centre for Mechanisms of Human Toxicity, introduced him to DNA adducts. He now has over 24 years’ experience, and 128 publications, in the translational study of nuclear, mitochondrial, and urinary DNA adducts, primarily associated with oxidative stress, but also UV radiation and, more recently, those associated with tobacco and certain volatile organic agents. 
Dr. Cooke is a pioneer of urinary DNA adductomics, and more recently nucleic acid adductomics (extending the scope of DNA adductomics to include RNA and DNA/RNA- plus DNA- and RNA-crosslinks). He has also employed genome-wide mapping of DNA adducts to study the induction and removal of cyclobutene thymine dimers, and 8-oxodG, in nuclear and mitochondrial DNA. His research interested center around determining the role of the endogenous and exogenous exposome in environmentally-linked diseases.
Dr. Cooke has played a key role in numerous international consortia including the European Standards Committee on Oxidative DNA Damage (ESCODD) , the European Standards Committee on Urinary (DNA) Lesion Analysis (ESCULA, of which he was founding chair), and the EU-funded COST projects EU-ROS and hCOMET.

Silvia Balbo

Silvia Balbo is an Assistant Professor of the School of Public Health at the University of Minnesota. She is part of the Division of Environmental Health Science and member of the Masonic Center Center. Dr. Balbo got her MS and Ph.D. in Medical Chemistry, at the University of Torino, in Torino, Italy after her doctoral work at the Vrije Universiteit Brussel, in Belgium. She spent time as a Post-doctoral fellow at the International Agency for Research on Cancer (IARC) in Lyon, France. Dr. Balbo then moved to the Masonic Cancer Center of the University of Minnesota and joined the faculty in the Division of Environmental Health Sciences in the School of Public Health in 2014. She is currently studying in the interaction of DNA and chemicals to investigate how lifestyle and environmental exposures cause disease. Her work focuses on studying mechanisms of chemical carcinogenesis, in particular those related to alcohol and tobacco exposures. She is developing more accurate methods to quantify the genotoxic effects deriving from these exposures and thus to measure the corresponding DNA damage. She is drawing upon her expertise in organic synthesis, analytical chemistry, cell culture and molecular epidemiology to develop integrated approaches aiming at quantifying DNA samples collected in clinical trials and molecular epidemiology studies.

William E. Funk 

​Bill Funk is an Associate Professor in the Department of Preventive Medicine at Northwestern University. In addition to his primary appointment, he serves as faculty in the Driskill Graduate Program in Life Sciences and is a full member of the Robert H. Lurie Comprehensive Cancer Center. Dr. Funk received his PhD in Environmental Sciences and Engineering from the University of North Carolina at Chapel Hill and has over 15 years of experience developing and applying biomarker methods with environmental health applications. Dr. Funk is a pioneer in the field of protein adductomics, which involves globally profiling protein addition products (i.e., adducts) to investigate links between environmental exposures and adverse health outcomes. In addition, his research focuses on adapting biomarker methods to dried blood spot (DBS) sampling as a minimally invasive alternative to venous blood collection in epidemiological research, with an emphasis on prenatal and pediatric populations. Current projects in his lab are focused on identifying environmental risk factors for breast cancer, autism spectrum disorders, bronchopulmonary dysplasia, and cardiovascular disease.

Sonia Dagnino

​​Sonia Dagnino is a Professor at the Université Cote d’Azur, leading the Exposome branch within the Transporters in Imaging and Radiotherapy in Oncology group. She also holds a visiting Professorship at Imperial College London, contributing to the MRC Centre for Environment and Health. With a PhD in Environmental Science from the University of Montpellier, Dr. Dagnino has cultivated an international career, encompassing roles in the United States (US EPA, University of Arizona, UC Berkeley) and the United Kingdom (Queen Mary University and Imperial College). Her research is at the forefront of omics-based methodologies, focusing on the comprehensive characterization of the Human Exposome. Dr. Dagnino's primary objective is to discern molecular signatures of environmental exposure intricately linked to adverse health outcomes, particularly emphasizing Cancer and Cardiovascular diseases. During her stay at UC Berkeley collaborating with S. Rappaport, she was introduced to protein adductomics, a field she continues to advance while fervently advocating for its pivotal role in elucidating the human exposome.

Yukari Totsuka

Yukari Totsuka is a Professor at Nihon University School of Pharmacy in the Laboratory of Environmental Toxicology and Carcinogenesis and a visiting scientists at the National Cancer Center Research Institute in the Division of Cancer Pathophysiology. Dr. Totsuka received her PhD at the Graduate School of Meiji Pharmaceutical University. Her research focuses on the analysis of carcinogenic heterocyclic amine-DNA adducts and studies the co-mutagenic action of β-carboline compounds and aromatic amines. Currently, she is working on the identification of human cancer causations using whole genome analysis and DNA Adductomics and establishing a novel genotoxicity assay system using organoids.

External Advisory Board of the International Adductomics Consortium

​​Dr. Suramya Waidyanatha

​Dr. Haruhiko Sugimura

​Prof. David Phillips

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Members

Region	Name	Institute	Home URL	IAC Status
US	Prof. Marcus Cooke	University of South Florida	​Oxidative Stress Group​	Chair
US	Prof. Silvia Balbo	University of Minnesota	Balbo Research Group​	Committee
US	Prof. Bill Funk	Northwestern University	labs.feinberg.northwestern.edu/funk/index.html	Comittee​
FR	Prof. Sonia Dagnino	​​Université Cote d'Azur	www.imperial.ac.uk/people/sonia.dagnino	Committee
US	Prof. Robert Turesky​	​Masonic Cancer Center and Department of Medicinal Chemistry, University of Minnesota	​https://sites.google.com/umn.edu/tureskylab/home​	Member
US	Dr. Scott Walmsley	​Masonic Cancer Center, University of Minnesota	​https://experts.umn.edu/en/persons/scott-j-walmsley	Member
US	Prof. Natalia Tretyakova	Department of Medicinal Chemistry, University of Minnesota	https://sites.google.com/a/umn.edu/tretyakova/	Member​
US	Prof. Yinsheng Wang	University of California Riverside	https://wanglab.ucr.edu	Member​
US	Prof. Roger W Giese	Department of Pharmaceutical Sciences, Northeastern University	https://bouve.northeastern.edu/bchs/directory/roger-giese/	Member​
US	Prof. Peter Villalta	Masonic Cancer Center, University of Minnesota		Member
US	Prof. Steven Hecht	Masonic Cancer Center, University of Minnesota		Member
US	Dr. Lauren Petrick	Environmental Medicine & Public Health, Icahn School of Medicine at Mount Sinai	https://www.petrickexposomelab.com	Affiliate member
US	Prof. Peter Dedon	Dept Biological Engineering, MIT		Member
US	​Dr. Suramya Waidyanatha​	Division of Translational Toxicology, NIEHS	​https://www.niehs.nih.gov/research/atniehs/labs/pob/staff/suramya/index.cfm	External advisory board
JP	​Prof. Robert A Kanaly​	Graduate School of Nanobioscience, Yokohama City University	http://www-user.yokohama-cu.ac.jp/~envmicro/kanaly/	Member
JP	Dr. Haruhiko Sugimura	Department of Tumor Pathology, Hamamatsu University School of Medicine	​www.hama-med.ac.jp/uni-e/academics/fac-med/dept/tumor-pathol/faculty.html	External advisory board
JP	​Prof. Yukari Totsuka	School of Pharmacy, Nihon University	​https://jglobal.jst.go.jp/en/detail?JGLOBAL_ID=201801003812530183	Committee
JP	Tomonari Matsuda	Research Center for Environmental Quality Management, Kyoto Univ., Shiga, ​​		Member
JP	Yuji Iwashita	​Aich Cancer Center		Member
US	Prof. Stephen M Rappaport	​Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley	​https://circle.berkeley.edu/team/stephen-rappaport/
EU​	Dr. Lieselot Hemerck	​Department of Translational Physiology, Infectiology and Public Health, Ghent University	www.ugent.be/di/vpi/en/research/limet	Member
EU	Dr. Hitesh Motwani	​Department of Environmental Sciences (ACRS)
EU	Dr. Giorgia La Barbera	Department of Nutrition Exercise and Sports, University of Copenhagen		Member
UK	Prof. David Phillips	​MRC-PHE Centre for Environment & Health, King's College London	www.kcl.ac.uk/people/professor-david-phillips	External Advisory Board
CA	Dr. Yong-Lai Feng	Exposure and Biomonitoring Division, Heath Canada	profils-profiles.science.gc.ca/en/profile/yong-lai-feng-phd​	Member
TW	Prof. Mu-Rong Chao	​Department of Occupational Safety and Health, Chung Shan Medical University	w3.csmu.edu.tw/~chaohulab/eechao.htm	Member
TW	Prof. Chiung-Wen	​Department of Public Health, Chung Shan Medical University	w3.csmu.edu.tw/~chaohulab/aaaa.htm	Member
TW	Dr. Yet-Ran Chen	​Agricultural Biotechnology Research Center, Academia Sinica	abrc.sinica.edu.tw/facultyE/?id=yetran	Member